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Letters from our family to yours.

Evidence-based reads on inflammation, mobility, absorption, ingredient science, recovery, and everyday nutrition — the research behind ProleevaMax, in plain language.

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Fresh off the press — the newest reads across every topic.

product-bottle, gradient-background, platformPain & Inflammation Signals

How to Test for Chronic Inflammation: What hs-CRP, ESR, and Homocysteine Actually Tell You

A pharma-led guide to testing for chronic inflammation: what hs-CRP, ESR, and homocysteine measure, how to read the ranges, the chronic-vs-acute distinction, and what the evidence says to do if levels are elevated.

·Fabio Lanzieri
human legs, ocean water, beach activityRecovery & Resilience

Why Chronic Inflammation Makes You Exhausted — And What the Cytokine Research Shows

Chronic low-grade inflammation drives fatigue through the cytokine-induced sickness-behavior pathway. What the research shows about why you are always tired, and where Panax ginseng and matcha genuinely fit.

·Maria Lanzieri
person lying on earth, desert landscape, mountainsRecovery & Resilience

The Estrogen-Serotonin Axis: What 5-HTP Actually Does for Perimenopause Mood

How falling estrogen affects the serotonin system in perimenopause, what 5-HTP (and its B6 cofactor) actually supports for mood, and why the research does not support a hot flash claim.

·Maria Lanzieri
product-bottle, bark-texture, woodIngredients Deep Dives

Boswellia vs. Celecoxib for Osteoarthritis: What a 24-Week Equivalence Trial Actually Showed

A pharma-led comparison of Boswellia serrata and celecoxib (Celebrex) for knee osteoarthritis, with an honest reading of the 24-week Chopra equivalence trial and the 5-LOX vs. COX-2 mechanism distinction.

·Fabio Lanzieri
open window, interior framing, landscape viewPain & Inflammation Signals

The Inflammation-Anxiety Loop: What the Cytokine Research Actually Shows

How chronic inflammatory cytokines like IL-6 and TNF-alpha interact with the brain to heighten anxiety, what the cohort research shows, and where GABA, 5-HTP, and resveratrol genuinely fit.

·Maria Lanzieri
person in motion, water/ocean, movementRecovery & Resilience

Panax Ginseng for Fatigue: What a Meta-Analysis of 12 RCTs Actually Found

After 40 years in pharma, Fabio Lanzieri reads the ginseng fatigue trials: a 2022 meta-analysis of 12 RCTs (1,298 patients) shows a small but real benefit for disease-related fatigue, the ginsenoside and HPA-axis mechanism, and an honest look at where it beats placebo and where it doesn't.

·Fabio Lanzieri
arm, shoulder, tennis court, athletic motionPain & Inflammation Signals

Perimenopause Hip Pain: The Connective Tissue and Inflammation Mechanism Behind It

Why new hip pain in perimenopause is often driven by estrogen loss and soft-tissue inflammation, not worn cartilage. The trochanteric-pain mechanism, the boswellia and curcumin evidence, and honest limits — with real citations.

·Fabio Lanzieri
abstract color gradient, blurred shapes, soft transitionsRecovery & Resilience

5-HTP for Sleep: The Serotonin-to-Melatonin Pathway Explained

How 5-HTP supports sleep through the serotonin-to-melatonin pathway, why it is not a sedative, what the human sleep research actually shows, and how the B6 cofactor fits in.

·Cristina Lanzieri
LanFam Bottle Laboratory Glass Beaker SetupIngredients Deep Dives

Does Boswellia Increase Estrogen? What the Research Actually Says

Does boswellia increase estrogen? No — boswellia isn't a phytoestrogen. Here's what the research actually shows about boswellia and your hormones.

·Fabio Lanzieri

Pain & Inflammation Signals

How the body signals inflammation — and what the research says about reading it.

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product-bottle, gradient-background, platformPain & Inflammation Signals

Latest

How to Test for Chronic Inflammation: What hs-CRP, ESR, and Homocysteine Actually Tell You

A pharma-led guide to testing for chronic inflammation: what hs-CRP, ESR, and homocysteine measure, how to read the ranges, the chronic-vs-acute distinction, and what the evidence says to do if levels are elevated.

·Fabio Lanzieri
open window, interior framing, landscape viewPain & Inflammation Signals

The Inflammation-Anxiety Loop: What the Cytokine Research Actually Shows

How chronic inflammatory cytokines like IL-6 and TNF-alpha interact with the brain to heighten anxiety, what the cohort research shows, and where GABA, 5-HTP, and resveratrol genuinely fit.

·Maria Lanzieri
arm, shoulder, tennis court, athletic motionPain & Inflammation Signals

Perimenopause Hip Pain: The Connective Tissue and Inflammation Mechanism Behind It

Why new hip pain in perimenopause is often driven by estrogen loss and soft-tissue inflammation, not worn cartilage. The trochanteric-pain mechanism, the boswellia and curcumin evidence, and honest limits — with real citations.

·Fabio Lanzieri
abstract color gradient, blurred shapes, soft transitionsPain & Inflammation Signals

Can You Take Turmeric and Ibuprofen Together?

Can you take turmeric and ibuprofen together? For most healthy adults the occasional combination is low-risk — here's when it isn't, from someone who spent 40 years in pharma.

·Fabio Lanzieri
6a0325e05d855f0dda177366_grocery-list-inflammatory-response-inline-01.jpgPain & Inflammation Signals

Best Supplements for Menopause Joint Pain: What the Research Actually Supports

The best supplements for menopause joint pain, graded by real trial evidence — boswellia, curcumin, omega-3, collagen, and the honest gaps.

·Fabio Lanzieri
product-bottle, tilted-anglePain & Inflammation Signals

Menopause as a Pro-Inflammatory Transition: What the Immunology Research Shows

Estrogen restrains the master inflammatory switch NF-κB. As estrogen declines through menopause, NF-κB activity rises and inflammatory signaling turns up body-wide — which is why joint pain, brain fog, weight gain, and mood changes cluster together. The mechanism, the markers, and honest guidance, with real citations.

·Fabio Lanzieri
Joint stiffness playbook thumbnailPain & Inflammation Signals

The Joint Stiffness Playbook: A Complete Natural Management Strategy

A complete, evidence-based strategy for managing joint stiffness naturally — from morning routines and movement plans to nutrition, sleep positioning, and when to see a doctor.

·Fabio Lanzieri
hands, plated food, beetroot salad, sauce bowlPain & Inflammation Signals

Perimenopause Weight Gain and Inflammation: The Visceral Fat Mechanism Nobody Explains

Maria Lanzieri on perimenopause belly weight as a signaling problem, not a willpower one: how falling estrogen drives visceral fat and NF-kappaB inflammation, and what genuinely helps.

·Maria Lanzieri
6a19a86a664ebf97774bda6a_fibromyalgia-hero.jpgPain & Inflammation Signals

5-HTP and Chronic Pain — What the Fibromyalgia Research Actually Shows

Two Italian trials — Caruso 1990 (double-blind, placebo-controlled, n=50) and Sarzi Puttini 1992 (90-day open-label, n=200) — tested 5-HTP in fibromyalgia patients. Here's what the research actually found, the design limitations, and why serotonin's role in descending pain modulation is more important than its mood association.

·Fabio Lanzieri
6a19a8a301bbf3759e3b9b82_bioavailability-problem-inline-02.jpgPain & Inflammation Signals

Inflammaging — The Slow-Burning Process That Quietly Ages Everything

Inflammaging is the chronic, low-grade inflammatory baseline that rises with age and underlies cardiovascular disease, type 2 diabetes, neurodegeneration, and sarcopenia. Fabio Lanzieri — 40 years in pharma — explains the Franceschi and Furman research and what you can actually do about it.

·Fabio Lanzieri
hand, bathwater, recovery, mineral bathPain & Inflammation Signals

Perimenopause Inflammation Symptoms: Why You Hurt, Fog, and Fatigue All at Once

Why new joint pain, brain fog, gut changes, and fatigue in perimenopause share one root: rising inflammatory load as estrogen declines. The estradiol-CRP-IL-6 connection, mapped to symptoms, with honest guidance and real citations.

·Maria Lanzieri
6a032597c2a20cd823279df4_stress-mood-and-pain-inline-02.jpgPain & Inflammation Signals

The Inflammatory Cascade Explained: A Step-by-Step Guide to How Chronic Inflammation Actually Works

What the inflammatory cascade is, how it works step by step, and why chronic activation drives most modern disease. Clear, researcher-grade explanation.

·Fabio Lanzieri
69e9169357ecd12b50909f02_grocery-list-inflammatory-response-inline-02.jpgPain & Inflammation Signals

Best Supplements for Menopause Joint Pain: What the Research Actually Supports

8 supplements for menopause joint pain, ranked by real trial evidence — Boswellia, curcumin, omega-3, collagen. Doses, evidence grades, and honest gaps.

·Fabio Lanzieri
69e916129d97a582b4a9a212_what-i-wish-i-knew-inflammation-food-inline-01.jpgPain & Inflammation Signals

The Inflammatory Cascade Explained: A Step-by-Step Guide to How Chronic Inflammation Actually Works

Chronic inflammation isn't one thing — it's a cascade of seven steps your body keeps repeating. Here's the step-by-step, with what actually breaks it.

·Fabio Lanzieri
69e258b0b562522ef9d24679_lifestyle-kitchen-hands-mug-03-landscape.jpgPain & Inflammation Signals

What Is Neuroinflammation? (And Why Your Brain Fog Might Not Be "Just Stress")

Brain fog isn't always stress. Sometimes it's neuroinflammation — and the fix isn't more sleep. What it actually is, how to spot it, and what helps.

·Fabio Lanzieri
69e2580029c41a1aef341108_lifestyle-hand-bottle-bookshelves-14-landscape.jpgPain & Inflammation Signals

Natural Anti-Inflammatory for Back Pain: Why Most Treatments Miss the Root Cause

If you have been told your back pain is structural — a degenerating disc, a compressed nerve, or just "wear and tear" — that explanation is likely incomplete.

·Maria Lanzieri
69dc3f15a54be86fca47baee_Clinical%20-%203%20%205.pngPain & Inflammation Signals

Anti-Inflammatory Supplements for Joint Pain: What the Evidence Actually Says

If you've tried turmeric supplements and felt underwhelmed, you're not alone — and you're not imagining it.

·Fabio Lanzieri
69dc3edd30c528662c74eadc_Screenshot%202026-04-12%20at%2020.54.44.pngPain & Inflammation Signals

Signs of Chronic Inflammation: Is Your Body Sending You a Signal?

Tired, achy, foggy, or inflamed? Learn the most common signs of chronic inflammation and what multi-pathway support can do.

·Fabio Lanzieri
69dc3e31913c2be6aa3887b5_aLanfam%20%2005899.jpgPain & Inflammation Signals

How to Reduce Inflammation Naturally: The Complete Guide

Discover science-backed ways to reduce inflammation naturally — from diet and lifestyle changes to targeted botanicals. Plus, what actually works at the root level.

·Fabio Lanzieri
697a67b0603821085f5e958b_Lanfam%20-%20Location%20Shoot%20-%20_14%20%205.jpgPain & Inflammation Signals

The Science Behind Your Gut - Why 38 Trillion Bacteria Control More Than You Think

38 trillion microbes train your immune system, build neurotransmitters, and talk to your brain. The gut science nobody mentioned — and what actually helps.

·Fabio Lanzieri
69d58d6d2cbe8cffac874151_Visual.pngPain & Inflammation Signals

Inflammation and Brain Fog: The Biological Connection Most People Miss

Curcumin and ibuprofen both reduce inflammation through different pathways. One carries GI risk; one takes weeks. Here's what the clinical data shows.

·Fabio Lanzieri
69d58e67672eb51aeddd66fe_Catalogue%20-%209%20%205.pngPain & Inflammation Signals

The best anti-inflammatory supplement — what to look for, after 40 years in pharma

Omega-3, curcumin with piperine, boswellia, vitamin D have the strongest human evidence. A pharma scientist ranks the best anti-inflammatory supplements.

·Fabio Lanzieri
69d58c7719f8c0c567e09869_Lanfam%20-%20Location%20Shoot%20-%20_7%20%205.pngPain & Inflammation Signals

Gut Inflammation Supplements: How Your Gut Barrier Drives Whole-Body Inflammation

The best gut inflammation supplements target your gut barrier — not just symptoms. Learn how L-Glutamine, Curcumin, and Boswellia support intestinal integrity.

·Fabio Lanzieri
69d58c4524537865f5a7a06b_jiri-suchy-nvmVK78tE5I-unsplash.jpgPain & Inflammation Signals

Natural Alternative to Ibuprofen

Curcumin matched ibuprofen on pain in a head-to-head trial — with fewer GI events. The research-backed natural alternatives to ibuprofen, and their limits.

·Fabio Lanzieri
69b85fb9d664f41537203fed_697235b47c0c2a7add54cca3_about-hero.avifPain & Inflammation Signals

The Inflammation Cascade: What's Actually Happening When You Hurt

Chronic pain isn't tissue damage — it's an inflammation cascade your body keeps re-running. What's actually happening, and where to interrupt the loop.

·Fabio Lanzieri
69b2f6e5fe683c3eb37ee560_6978fb0de06fb88ba3a444a5_Lanfam%20-%20Location%20Shoot%20-%20_2%20%205.jpgPain & Inflammation Signals

Anti-Inflammatory Eating: A 7-Day Meal Plan That Actually Works

A 7-day anti-inflammatory meal plan built on peer-reviewed research — not food trends. What to eat, what to cut, and how to make it stick.

·Fabio Lanzieri
6977b47d874e9069903bf123_Lanfam%20-%20Location%20Shoot%20-%20%20%205.jpgPain & Inflammation Signals

Pain Signals and the Quieting Response—How GABA Modulates What You Feel

Chronic pain often persists with no tissue damage left to explain it. The reason lives in your nervous system — and GABA is how the brain quiets it.

·Fabio Lanzieri

Mobility & Daily Life

Staying mobile through the everyday — joints, movement, and the long game.

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69d58c0208c3733562a3758f_margaret-young--puYCDwwcHU-unsplash.jpgMobility & Daily Life

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Stiff Back in the Morning

Morning back stiffness isn't how you slept — it's inflammatory markers peaking overnight. What's driving it and what actually helps.

·Maria Lanzieri
Athlete warming up with gentle stretches in golden lightMobility & Daily Life

Moving Your Body When Your Body Says No

When chronic inflammation makes movement feel impossible, the answer isn't exercise — it's movement. Maria on the difference, the guilt, and the start.

·Maria Lanzieri

Absorption & Bioavailability

Why how much you absorb can matter more than how much you take.

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6977b64368afd4336e5d31d2_Lanfam%20-%20Location%20Shoot%20-%20_7%20%205.jpgAbsorption & Bioavailability

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The Conversation Between Your Two Brains—How Gut and Mind Shape Each Other

Your gut has more neurons than your spinal cord. The two-brain conversation that drives mood, immunity, and inflammation — and how to feed both sides.

·Fabio Lanzieri

Ingredients Deep Dives

One active at a time — the standardized compounds inside ProleevaMax, examined.

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product-bottle, bark-texture, woodIngredients Deep Dives

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Boswellia vs. Celecoxib for Osteoarthritis: What a 24-Week Equivalence Trial Actually Showed

A pharma-led comparison of Boswellia serrata and celecoxib (Celebrex) for knee osteoarthritis, with an honest reading of the 24-week Chopra equivalence trial and the 5-LOX vs. COX-2 mechanism distinction.

·Fabio Lanzieri
LanFam Bottle Laboratory Glass Beaker SetupIngredients Deep Dives

Does Boswellia Increase Estrogen? What the Research Actually Says

Does boswellia increase estrogen? No — boswellia isn't a phytoestrogen. Here's what the research actually shows about boswellia and your hormones.

·Fabio Lanzieri
butterfly specimen, wing pattern, eye spotsIngredients Deep Dives

Curcumin vs. Diclofenac: What the 139-Patient Head-to-Head Trial Actually Found

A pharmacist's-eye read of the Shep 2019 head-to-head RCT: standardized curcumin matched diclofenac on knee-osteoarthritis pain over 28 days with far fewer GI side effects (0% vs 28% needing H2 blockers). Honest framing on non-inferiority, the absorption caveat, and why this is a doctor conversation.

·Fabio Lanzieri
forest vegetation, plant life, woodland plantsIngredients Deep Dives

Piperine: Why Black Pepper Extract Is in Every Serious Anti-Inflammatory Supplement

A mechanism explainer on piperine (black pepper extract): how it raised curcumin bioavailability 2,000%, enhances resveratrol absorption, and quiets the NF-kB inflammation pathway directly.

·Fabio Lanzieri
flowers, macro photography, white blossomsIngredients Deep Dives

Boswellia vs. Ibuprofen for Inflammation: A Different Pathway, Not a Replacement

A pharmacist's-eye comparison of boswellia and ibuprofen: boswellic acids inhibit the 5-LOX/leukotriene pathway while ibuprofen inhibits COX/prostaglandins. Why they are complementary, not interchangeable, and what seven RCTs of boswellia for osteoarthritis actually found.

·Fabio Lanzieri
plant leaves, natural texture, botanical detailIngredients Deep Dives

Curcumin Dosage for Inflammation: What 29 RCTs Actually Show

A pharmacist's-eye answer to how much curcumin to take for inflammation: the 120-1,500 mg studied range, the practical 500 mg twice-daily target, why standardization and piperine co-administration decide whether the dose actually arrives.

·Fabio Lanzieri
turmeric or dried plant, botanical material, warm glowIngredients Deep Dives

Curcumin vs. Turmeric: What the Absorption Science Actually Means for Your Supplement

Turmeric is the root; curcumin is the active compound inside it. Why the curcuminoid percentage and curcumin's poor bioavailability mean standardized extract plus an absorption strategy is what the research is actually about.

·Fabio Lanzieri
6a19a8aedd255288faab04aa_moving-your-body-when-it-says-no-hero.jpgIngredients Deep Dives

L-Glutamine and the Gut Lining — The Amino Acid Your Intestinal Cells Actually Run On

Most gut-health content talks about probiotics and skips the cells holding the barrier together. L-glutamine is the primary metabolic fuel for enterocytes — the epithelial cells that form your intestinal lining. Here's the biology, the evidence, and where supplementation honestly fits.

·Fabio Lanzieri
69ef8f883ea8605273401c0a_sleep-pain-and-what-we-eat-thumb.jpgIngredients Deep Dives

Resveratrol Supplement Benefits: What the Sirtuin Research Actually Shows

Resveratrol activates the longevity pathway most supplements miss. What the SIRT1 research actually shows — and what dose actually moves the needle.

·Fabio Lanzieri
69d58d32236dcfa7fc9339eb_Texture%20-%203%20-%20Full-Res.pngIngredients Deep Dives

Looking for a natural alternative to ibuprofen? Here's what 40 years in pharma taught me

Forty years in pharma taught me to be careful with 'natural alternative' to ibuprofen. Here's when curcumin can stand in for daily NSAIDs — and when it can't.

·Fabio Lanzieri
69d58d9a9c83c21d8f245250_ed6355c6-3764-47f8-81a5-fd62592445df.pngIngredients Deep Dives

Boswellia vs Turmeric

Boswellia blocks 5-LOX. Turmeric targets COX-2. They hit different inflammatory pathways — here's when each wins and when you need both.

·Fabio Lanzieri
69d58e88f714b6cff6f50cba_Lanfam%20%2006287.jpgIngredients Deep Dives

Boswellia Serrata Benefits

Boswellia serrata targets the 5-LOX pathway turmeric can't reach. What the clinical research shows about dosing, standardization, and results.

·Fabio Lanzieri
Supplement ingredients and botanicals in a square flat layIngredients Deep Dives

Reading Labels When You’re Managing Inflammation

Maria shares her practical approach to reading food and supplement labels — the three things she checks first, why proprietary blends are a red flag, and how absorption changes everything.

·Maria Lanzieri
6977b487a9ef0255a50f2674_Lanfam%20-%20Location%20Shoot%20-%20_1%20%205.jpgIngredients Deep Dives

The Circulation Connection—How One Amino Acid Influences Everything That Flows

One amino acid produces the molecule that controls every blood vessel in your body. The nitric oxide story, and why circulation may be the missing lever.

·Fabio Lanzieri
6977b490a42814ab04150569_Lanfam%20-%20Location%20Shoot%20-%20_2%20%205.jpgIngredients Deep Dives

The Nutrient Your Brain Is Quietly Starving For—Understanding Choline's Essential Role

Most adults under-eat the one nutrient their brain runs on. The choline-acetylcholine story — and the simple fix for the memory and focus dip you feel.

·Fabio Lanzieri
6977b632e755632b7bff1e98_Lanfam%20-%20Location%20Shoot%20-%20_5%20%205.jpgIngredients Deep Dives

The Inflammation Paradox—How a Plant Defense Molecule Became a Human Therapeutic

The compound that protects plants from stress quietly does the same for human cells. How resveratrol crossed the species line — and what it does in you.

·Fabio Lanzieri
6977b6529403a1321b0d9b27_Lanfam%20-%20Location%20Shoot%20-%20_12%20%205.jpgIngredients Deep Dives

Ancient Molecules for Modern Stress—What Adaptogens Actually Do to Your Biology

Adaptogens aren't woo. They're plants that modulate the stress axis evolution couldn't redesign for modern life. What the actual research shows works.

·Fabio Lanzieri

Recovery & Resilience

Bouncing back and building resilience, from training loads to everyday stress.

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human legs, ocean water, beach activityRecovery & Resilience

Latest

Why Chronic Inflammation Makes You Exhausted — And What the Cytokine Research Shows

Chronic low-grade inflammation drives fatigue through the cytokine-induced sickness-behavior pathway. What the research shows about why you are always tired, and where Panax ginseng and matcha genuinely fit.

·Maria Lanzieri
person lying on earth, desert landscape, mountainsRecovery & Resilience

The Estrogen-Serotonin Axis: What 5-HTP Actually Does for Perimenopause Mood

How falling estrogen affects the serotonin system in perimenopause, what 5-HTP (and its B6 cofactor) actually supports for mood, and why the research does not support a hot flash claim.

·Maria Lanzieri
person in motion, water/ocean, movementRecovery & Resilience

Panax Ginseng for Fatigue: What a Meta-Analysis of 12 RCTs Actually Found

After 40 years in pharma, Fabio Lanzieri reads the ginseng fatigue trials: a 2022 meta-analysis of 12 RCTs (1,298 patients) shows a small but real benefit for disease-related fatigue, the ginsenoside and HPA-axis mechanism, and an honest look at where it beats placebo and where it doesn't.

·Fabio Lanzieri
abstract color gradient, blurred shapes, soft transitionsRecovery & Resilience

5-HTP for Sleep: The Serotonin-to-Melatonin Pathway Explained

How 5-HTP supports sleep through the serotonin-to-melatonin pathway, why it is not a sedative, what the human sleep research actually shows, and how the B6 cofactor fits in.

·Cristina Lanzieri
6a0325ba443956052279c7ed_cooking-for-someone-in-pain-inline-01.jpgRecovery & Resilience

Supplements for Menopause Belly Fat: What Targets the Visceral Inflammation Loop

The best supplements for menopause belly fat target the inflammation-insulin-visceral-fat loop — not appetite. Doses, mechanisms, and honest limits.

·Fabio Lanzieri
6a0325c8324cf01e48a48b48_what-i-wish-i-knew-inflammation-food-inline-02.jpgRecovery & Resilience

Supplements for Menopause Bloating: The Inflammation Link Most Articles Miss

The best supplements for menopause bloating, plus why estrogen decline drives gut inflammation — graded honestly, with the inflammation link most articles skip.

·Fabio Lanzieri
woman, bed, reading, beverage, self-careRecovery & Resilience

Why Perimenopause Causes Mood Swings — And What the Neurotransmitter Research Suggests

Perimenopausal mood swings are a neurochemical event, not a personality change. How estrogen decline drives inflammation and strains serotonin and GABA — and what the research suggests about 5-HTP, GABA, Panax ginseng, and vitamin B6.

·Maria Lanzieri
hand, bathtub edge, shadow pattern, natural light, morning ritualRecovery & Resilience

GABA for Anxiety and Stress: Does Oral GABA Actually Reach Your Brain?

Cristina Lanzieri tackles the blood-brain-barrier debate head-on: what oral GABA actually does for anxiety and stress, the gut-brain pathway, the placebo-controlled human studies (Abdou 2006, Yoto 2012), the honest limits, and how nervous-system hyperactivation and inflammation run together.

·Cristina Lanzieri
The sleep-pain cycleRecovery & Resilience

The Sleep-Pain Cycle: Why Hurting Keeps You Awake

Pain and sleep aren't separate problems. Your nervous system loops them together. The biology behind the cycle — and what actually broke it for Maria.

·Maria Lanzieri
woman-in-bed, holding-capsule, supplement-bottle, morningRecovery & Resilience

Why Perimenopause Wrecks Sleep — And What GABA, 5-HTP, and L-Serine Actually Do

Maria Lanzieri on why perimenopause causes the 3 a.m. wake-up: how falling estrogen and progesterone and rising inflammation disrupt sleep, and what GABA, 5-HTP, and L-serine each actually do.

·Maria Lanzieri
hand, bathtub, window light, warmth, restRecovery & Resilience

Perimenopause Fatigue Is Not Normal Tiredness — Here Is What the Inflammation Research Shows

Perimenopause fatigue is a metabolic and inflammatory event, not a willpower problem. How estrogen decline raises IL-6 and strains the HPA axis and mitochondria — and what the research suggests about Panax ginseng, resveratrol, L-serine, and GABA.

·Maria Lanzieri
69e915c518bfed8211368cdf_moving-your-body-when-it-says-no-inline-02.jpgRecovery & Resilience

The off-switch for inflammation — how your body resolves what it starts

Inflammation has two phases, not one. The resolution of acute inflammation is an active, programmed second wave governed by specialized pro-resolving mediators — resolvins, protectins, and maresins — derived from omega-3 fatty acids. Fabio Lanzieri explains the biology and what it means for what you eat.

·Fabio Lanzieri
69fb717ff3d11a7a76df7512_morning-drinks-we-actually-make-inline-01.jpgRecovery & Resilience

You Don't Have a Sleep Problem. You Have an Inflammation Problem.

Sleep rarely breaks in isolation — inflammation breaks it first. Inflammatory messengers — IL-6 and TNF-α — disrupt the deep, slow-wave sleep that actually repairs you. And then poor sleep makes inflammation worse. It's a loop, not a line. Most "sleep" interventions — melatonin, magnesium, sleep hygiene rules — help symptoms but don't touch the loop. Address the inflammation, and sleep tends to follow.

·Maria Lanzieri
69e915c518bfed8211368cdf_moving-your-body-when-it-says-no-inline-02.jpgRecovery & Resilience

Supplements for Menopause Bloating: The Inflammation Link Most Articles Miss

Menopause bloating isn't just food. Estrogen decline shifts three gut systems at once. The supplement protocol most articles miss — and what to try first.

·Fabio Lanzieri
69d58ba95ffeff9c4c786c9a_69d572ee56c374a0facd4f5e_gut-friendly-eating-week-thumb.jpgRecovery & Resilience

Best Supplements for Menopause Brain Fog

Discover the best supplements for menopause brain fog — from L-Serine to Choline to Curcumin. Learn why multi-pathway support outperforms single ingredients.

·Maria Lanzieri
69d58cfd11596c3d14f6ac8e_Screenshot%202026-04-07%20at%2019.02.19.pngRecovery & Resilience

Brain Fog Supplements: What Actually Works (and What Doesn't)

The best supplements for brain fog target neuroinflammation, not just focus — 5-HTP, GABA, matcha EGCG, curcumin. See which cross the blood-brain barrier.

·Maria Lanzieri
6977b62a9d1903f6df4558e0_Lanfam%20-%20Location%20Shoot%20-%20_4%20%205.jpgRecovery & Resilience

The Neurochemistry of Feeling Good—What Actually Moves the Needle on Mood

Mood doesn't come from one neurotransmitter. The four chemistry pathways that actually move the needle — and the daily habits that nudge each of them.

·Maria Lanzieri
6977b658e037fad123b0dddd_Lanfam%20-%20Location%20Shoot%20-%20_15%20%205.jpgRecovery & Resilience

The Architecture of Rest—How Sleep Rebuilds What Waking Hours Tear Down

Sleep isn't downtime — it's the most active repair process your body runs. The architecture of the four stages, and what each one rebuilds.

·Maria Lanzieri
6977b64b6bffdec2c5f9a565_Lanfam%20-%20Location%20Shoot%20-%20_9%20%205.jpgRecovery & Resilience

The Case for Disconnection—Why Your Brain Needs Silence from Screens

The brain that evolved to track predators now processes 74GB a day. What constant input does to your nervous system — and the case for daily silence.

·Maria Lanzieri
6977b66185a0199da7164f5e_Lanfam%20-%20Location%20Shoot%20-%20_16%20%205.jpgRecovery & Resilience

The Biology of Not Eating—What Happens When You Give Your Body a Break

Cellular repair only switches on when you stop eating. The autophagy literature in plain language — and the realistic time-restricted window to start.

·Maria Lanzieri

Nutrition & Recipes

Anti-inflammatory eating made practical — meals, ingredients, and habits.

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6a19a8b761facbefc5207e5d_reading-labels-managing-inflammation-hero.jpgNutrition & Recipes

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Why matcha — what daily green tea actually does for inflammation and stress

Maria Lanzieri on matcha as a daily ritual: the EGCG and L-theanine evidence, why consistency matters more than dose, and how a cup of tea fits inside a life that supports a healthy inflammatory response.

·Maria Lanzieri
6a03257274a41a6caf0cf4ac_grocery-list-inflammatory-response-thumb.jpgNutrition & Recipes

Anti-Inflammatory Breakfast: 7 Research-Backed Ideas to Start Your Day With Less Inflammation

7 anti-inflammatory breakfast ideas backed by peer-reviewed research. What to eat (and skip) in the first hour to lower inflammatory markers all day.

·Fabio Lanzieri
69e8f647311fee9cdfe6fd5c_weeknight-meals-inflammatory-response-hero.jpgNutrition & Recipes

Anti-Inflammatory Breakfast: 7 Research-Backed Ideas to Start Your Day With Less Inflammation

Most breakfasts spike inflammation before you finish your coffee. Seven research-backed swaps that calm the cortisol-glucose loop instead of feeding it.

·Maria Lanzieri

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